Atagabalin

Atagabalin (PD 0200390) is a selective GABA (gamma-aminobutyric acid) receptor agonist with antianxiety and sedative effects. Atagabalin enhances the activity of the GABA receptor by binding to the α2δ subunit of the GABA receptor, thereby increasing the GABA mediated inhibition. This enhancement results in reduced excitability of neurons, helping to reduce anxiety and improve sleep. Atagabalin can be used to study neuropsychiatric disorders, anxiety or sleep disorders[1].

Product Specifications

CAS Number

[223445-75-8]

Product Name Alternative

PD 0200390

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/atagabalin.html

Smiles

O=C(O)CC1(CN)C[C@H](C)[C@@H](C)C1

Molecular Formula

C10H19NO2

Molecular Weight

185.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Corrigan B, et al. Effect of renal impairment on the pharmacokinetics of PD 0200390, a novel ligand for the voltage‐gated calcium channel alpha‐2‐delta subunit[J]. British journal of clinical pharmacology, 2009, 68 (2) : 174-180.