LY 345899
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1[1][2][3].
Product Specifications
CAS Number
10538-99-5
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY_345899.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](NC(C1=CC=C(N2C(N3C4=C(NC(N)=NC4=O)NCC3C2)=O)C=C1)=O)CCC(O)=O
Molecular Formula
C20H21N7O7
Molecular Weight
471.42
Precautions
H302, H312, H332
References & Citations
[1]Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39 (21) :6325-35.|[2]Tedeschi PM, et al. Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development. Mol Cancer Res. 2015 Oct;13 (10) :1361-6.|[3]Gustafsson R, et al. Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Cancer Res. 2017 Feb 15;77 (4) :937-948.|[4]Huai-Qiang Ju, et al.Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. J Natl Cancer Inst. 2019 Jun 1;111 (6) :584-596.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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