VU0155094

VU0155094 is a positive allosteric modulator with differential activity at the various group III mGluRs[1].

Product Specifications

CAS Number

[731006-86-3]

Product Name Alternative

ML397

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0155094.html

Concentration

10mM

Purity

98.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CC=C(N2C(C)=C(C(CSC3=CC=C(NC(C)=O)C=C3)=O)C=C2C)C=C1

Molecular Formula

C24H24N2O4S

Molecular Weight

436.52

Precautions

H315, H319, H320

References & Citations

[1]Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5 (12) :1221-37.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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