HIV-1 inhibitor-66
HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI) . HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC50 of 40 nM[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-66.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C=CC(C(F)(F)F)=C1OC2=CC(C3=CC=C(C=C3)Br)=CC(Cl)=C2)CC4=NNC(N4C)=O
Molecular Formula
C22H15BrClF3N4O3
Molecular Weight
555.73
References & Citations
[1]Yanying Sun, et al. Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. J Med Chem. 2024 Apr 25;67 (8) :6570-6584.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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