HIV-1 inhibitor-66

HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI) . HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC50 of 40 nM[1].

Product Specifications

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-66.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C=CC(C(F)(F)F)=C1OC2=CC(C3=CC=C(C=C3)Br)=CC(Cl)=C2)CC4=NNC(N4C)=O

Molecular Formula

C22H15BrClF3N4O3

Molecular Weight

555.73

References & Citations

[1]Yanying Sun, et al. Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. J Med Chem. 2024 Apr 25;67 (8) :6570-6584.