RO-275

RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder[1][2].

Product Specifications

CAS Number

[2648837-04-9]

UNSPSC

12352005

Target

HCN Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ro-275.html

Purity

99.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC(C#CC2=C(C)C(Cl)=NC=C2)=C(C)N1C3=CC=CN=C3)N

Molecular Formula

C18H14ClN5O

Molecular Weight

351.79

References & Citations

[1]Bjoern Bartels, et al. Alkynyl- (heteroaryl) -carboxamide hcn1 inhibitors. WO2021110574A1.|[2]Harde E, et al. Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell Chem Biol. 2024 Mar 21;31 (3) :577-592.e23.