Talsaclidine

Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes[1][2][3][4]. Talsaclidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[147025-53-4]

UNSPSC

12352005

Hazard Statement

H318

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/talsaclidine.html

Purity

98.75

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

C#CCO[C@@H]1[C@@H]2CCN(CC2)C1

Molecular Formula

C10H15NO

Molecular Weight

165.24

Precautions

H318

References & Citations

[1]Ensinger HA, et al. WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties. Life Sci. 1993;52 (5-6) :473-80.|[2]Wienrich M, et al. Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life Sci. 2001 Apr 27;68 (22-23) :2593-600.|[3]Walland A, et al. In vivo consequences of M1-receptor activation by talsaclidine. Life Sci. 1997;60 (13-14) :977-84.|[4]Walland A, et al. Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs. Eur J Pharmacol. 1997 Jul 9;330 (2-3) :213-9.