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DBCO-Val-Cit-PAB-MMAE

DBCO-Val-Cit-PAB-MMAE is a drug-linker conjugate, which can be used for the synthesis of ADC molecules. MMAE (HY-15162) is a tubulin inhibitor, which can be used as an ADC toxin. DBCO-Val-Cit-PAB is the linker with the electrophilic group[1].

Product Specifications

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-val-cit-pab-mmae.html

Purity

98.33

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C77H107N11O14

Molecular Weight

1410.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang W, et al., Affinity fragment-directed cleavable fragments, their design, synthesis and use in the preparation of site-directed drug conjugates. CN116836235 A.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W591408/DBCO-Val-Cit-PAB-MMAE-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W591408/DBCO-Val-Cit-PAB-MMAE-SDS-MedChemExpress.pdf

Scientific Category

ADC Related

Clinical Information

No Development Reported

CAS Number

[2768446-73-5]

Available Sizes

Curated Selection

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