Felbinac

Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity[2][3][4].

Product Specifications

CAS Number

[5728-52-9]

Product Name Alternative

4-Biphenylacetic acid

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Felbinac.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

O=C(O)CC1=CC=C(C2=CC=CC=C2)C=C1

Molecular Formula

C14H12O2

Molecular Weight

212.25

Precautions

H301, H315, H319, H335

References & Citations

[1]Van Eerdenbrugh B, et al. 2- (Biphenyl-4-yl) acetic acid (felbinac) . Acta Crystallogr Sect E Struct Rep Online.|[2]Bhagyashri Kasabe, et al. Drug repurposing approach against chikungunya virus: an in vitro and in silico study. Front Cell Infect Microbiol. 2023 Apr 27:13:1132538. |[3]Fumiyo Kasuya, et al. Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues. Int J Toxicol. 2011 May;30 (3) :367-76.|[4]Shah Alam Khan, et al. Synthesis, molecular docking with COX 1& II enzyme, ADMET screening and in vivo anti-inflammatory activity of oxadiazole, thiadiazole and triazole analogs of felbinac.Journal of Saudi Chemical Society. Volume 22, Issue 4