S1PL-IN-1
S1PL-IN-31 (compound) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC50 of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC50 of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis[1][2].
Product Specifications
CAS Number
1538574-95-6
UNSPSC
12352005
Target
LPL Receptor; Smo
Type
Reference compound
Related Pathways
GPCR/G Protein; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s1pl-in-1.html
Smiles
C[C@@H](N(C1=CC=C(C=N1)C#N)CC2)CN2C3=NN=C(C4=C3C=C(C=C4)Cl)CC5=CC=CC=C5
Molecular Formula
C26H23ClN6
Molecular Weight
454.95
References & Citations
[1]Weiler S, et al. Orally active 7-substituted (4-benzylphthalazin-1-yl) -2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J Med Chem. 2014;57 (12) :5074-5084. |[2]Harris CM, et al. Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. J Pharmacol Exp Ther. 2016;359 (1) :151-158.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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