AZD7507
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
Product Specifications
CAS Number
[1041852-85-0]
Product Name Alternative
CXD101
UNSPSC
12352005
Hazard Statement
H302
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD7507.html
Purity
99.57
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(N)C1=NN=C2C=C(C(N3CCN(CC3)CCO)=CC2=C1NC4=CC=C(C=C4F)C)OC
Molecular Formula
C23H27FN6O3
Molecular Weight
454.50
Precautions
H302
References & Citations
[1]Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23 (16) :4591-6.|[2]Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125 (3) :1269-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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