Pefloxacin-d3
Pefloxacin-d3 (Pefloxacinium-d3) is the deuterium labeled Pefloxacin (HY-B0147) . Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies[1][2][3][4][5][6][7][8][9].
Product Specifications
CAS Number
[2733455-58-6]
Product Name Alternative
Pefloxacinium-d3
UNSPSC
12352005
Target
Antibiotic; Bacterial; DNA/RNA Synthesis; Isotope-Labeled Compounds; Parasite; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection; Inflammation/Immunology
Purity
99.35
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCN(C([2H])([2H])[2H])CC3)=C2)C1=O)O
Molecular Formula
C17H17D3FN3O3
Molecular Weight
336.38
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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