Talotrexin (monoammonium)
Talotrexin monoammonium is the monoammonium salt form of Talotrexin. Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a reduced folate carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].
Product Specifications
CAS Number
648420-92-2
Product Name Alternative
PT523 (monoammonium)
UNSPSC
12352005
Target
Antifolate; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/talotrexin-monoammonium.html
Smiles
NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2.N
Molecular Formula
C27H30N10O6
Molecular Weight
590.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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