NRX-1933

NRX-1933 is a type of molecular glue. NRX-1933 is a β-catenin:β-TrCP interaction enhancer for the development of small molecule degraders. NRX-1933 promotes the ubiquitination of mutated β-Catenin, leading to degradation. NRX-1933 can be applied to tumor research on abnormal activation of Wnt/β - catenin signaling pathway[1][2].

Product Specifications

CAS Number

[2763260-30-4]

UNSPSC

12352005

Target

Molecular Glues; β-catenin

Type

Reference compound

Related Pathways

PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nrx-1933.html

Concentration

10mM

Purity

99.51

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C(F)(F)F)NC1=O)NC2=CC=CC(C3=NNN=N3)=C2

Molecular Formula

C14H9F3N6O2

Molecular Weight

350.26

References & Citations

[1]Simonetta KR, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10 (1) :1402. |[2]Hu Y, et al. Molecular glue degrader for tumor treatment. Front Oncol. 2024 Dec 12;14:1512666.