Farnesyl pyrophosphate (ammonium)

Farnesyl pyrophosphate (Farnesyl diphosphate) ammonium is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate ammonium is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate ammonium is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases[1][2][3].

Product Specifications

CAS Number

[116057-57-9]

Product Name Alternative

Farnesyl diphosphate (ammonium)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Calcium Channel; Endogenous Metabolite; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/farnesyl-pyrophosphate-ammonium.html

Purity

97.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=P(O)(O)OP(OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(O)=O.N.N.N

Molecular Formula

C15H37N3O7P2

Molecular Weight

433.42

Precautions

H315, H319, H335

References & Citations

[1]Jing Chen, et al. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biol. 2021 Apr 26;19 (4) :e3001134.|[2]Qi XF, et al. Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells. Toxicol Lett. 2010 Dec 15;199 (3) :277-87.|[3]Zhang J, et al. Statins directly suppress cytokine production in murine intraepithelial lymphocytes. Cytokine. 2013 Feb;61 (2) :540-5.