YAP-TEAD-IN-1
Product Specifications
UNSPSC Description
YAP-TEAD-IN-1 is a potent and competitive inhibitor of?YAP–TEAD interaction (IC50=25 nM). YAP-TEAD-IN-1 is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50-171) (Kd=40 nM)[1].
Target Antigen
YAP
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yap-tead.html
Purity
99.69
Solubility
H2O : 35 mg/mL (ultrasonic;warming)
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@H](C(N)=O)CCC(O)=O)=O)[C@H](CCC2)N2C([C@H](CCCCN)NC(C(CSSCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H]3CCCCN)=O)CCCNC(N)=N)=O)CC(C)C)=O)NC([C@H](CC4=CC(Cl)=CC=C4)NC([C@H](CCC5)N5C([C@H](C(C)C)NC(C)=O)=O)=O)=O)NC([C@@H](NC([C@](NC([C@@H](NC([C@@](CCC6)([H])N6C([C@](NC3=O)([H])CCCC)=O)=O)C)=O)([H])CO)=O)CC7=CC=CC=C7)=O)=O)=O
Molecular Weight
2019.86
References & Citations
[1]Zhang Z, et al. Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.ACS Med Chem Lett. 2014 Jul 14;5(9):993-8.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2244/YAP-TEAD-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2244/YAP-TEAD-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1659305-78-8
Available Sizes
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