AGI-5198
AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM.
Product Specifications
CAS Number
1355326-35-0
Product Name Alternative
IDH-C35
UNSPSC
12352005
Hazard Statement
H301
Target
Isocitrate Dehydrogenase (IDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AGI-5198.html
Purity
99.93
Solubility
DMF : ≥ 50 mg/mL|DMSO : 20.83 mg/mL (ultrasonic)
Smiles
FC1=CC=CC(N(C(C2=CC=CC=C2C)C(NC3CCCCC3)=O)C(CN4C=CN=C4C)=O)=C1
Molecular Formula
C27H31FN4O2
Molecular Weight
462.56
Precautions
H301
References & Citations
[1]Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340 (6132) :626-30.|[2]Molenaar RJ, et al. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Cancer Res. 2015 Nov 15;75 (22) :4790-802.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1
Available Sizes
Frequently Asked Questions
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