AGI-5198

AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM.

Product Specifications

CAS Number

[1355326-35-0]

Product Name Alternative

IDH-C35

UNSPSC

12352005

Hazard Statement

H301

Target

Isocitrate Dehydrogenase (IDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AGI-5198.html

Purity

99.93

Solubility

DMF : ≥ 50 mg/mL|DMSO : 20.83 mg/mL (ultrasonic)

Smiles

FC1=CC=CC(N(C(C2=CC=CC=C2C)C(NC3CCCCC3)=O)C(CN4C=CN=C4C)=O)=C1

Molecular Formula

C27H31FN4O2

Molecular Weight

462.56

Precautions

H301

References & Citations

[1]Rohle D, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340 (6132) :626-30.|[2]Molenaar RJ, et al. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Cancer Res. 2015 Nov 15;75 (22) :4790-802.