TD1092
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research[1].
Product Specifications
CAS Number
[3037417-26-5]
UNSPSC
12352005
Target
Caspase; IAP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/td1092.html
Purity
99.49
Solubility
DMSO : ≥ 100 mg/mL
Smiles
Molecular Formula
C55H70N8O9
Molecular Weight
987.19
References & Citations
[1]Park S, et al. Discovery of pan-IAP degraders via a CRBN recruiting mechanism. Eur J Med Chem. 2023 Jan 5;245 (Pt 2) :114910.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; cIAP-1; cIAP-2; XIAP
Available Sizes
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