RPR121056
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].
Product Specifications
CAS Number
[181467-56-1]
Product Name Alternative
APC
UNSPSC
12352005
Hazard Statement
H301
Target
Cholinesterase (ChE) ; Drug Metabolite; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rpr121056.html
Purity
99.88
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(NCCCCC(O)=O)CC1)OC2=CC=C3N=C4C(CN5C(C(COC([C@@]6(CC)O)=O)=C6C=C54)=O)=C(CC)C3=C2
Molecular Formula
C33H38N4O8
Molecular Weight
618.68
Precautions
H301
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
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