2'-O-MOE-rC

2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA[1][2].

Product Specifications

CAS Number

[251647-54-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-o-moe-rc.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C=C5)=O)O4

Molecular Formula

C49H58N5O10P

Molecular Weight

907.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Prakash TP, et al. Comparing in vitro and in vivo activity of 2'-O-[2- (methylamino) -2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides. J Med Chem. 2008 May 8;51 (9) :2766-76.|[2]Li M, et al. Synthesis and cellular activity of stereochemically-pure 2'-O- (2-methoxyethyl) -phosphorothioate oligonucleotides. Chem Commun (Camb) . 2017 Jan 3;53 (3) :541-544.