OXSI-2

OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].

Product Specifications

CAS Number

[622387-85-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Syk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oxsi-2.html

Purity

95.00

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC2=C(NC(/C2=C/C3=CN(C)C4=C3C=CC=C4)=O)C=C1)(N)=O

Molecular Formula

C18H15N3O3S

Molecular Weight

353.40

Precautions

H315, H319, H335

References & Citations

[1]Kamala Bhavaraju, et al. Evaluation of [3- (1-methyl-1H-indol-3-yl-methylene) -2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol. 2008 Feb 12;580 (3) :285-90.|[2]Jordan R Yaron, et al. The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem Biophys Res Commun. 2016 Apr 8;472 (3) :545-50.