XZ739

XZ739, a Cereblon-dependent PROTAC BCL-XL (Bcl-2 family member) degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

Product Specifications

CAS Number

[2365172-19-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Apoptosis; Bcl-2 Family; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xz739.html

Purity

99.06

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(N2CCN(CC3=C(C4=CC=C(Cl)C=C4)CCC(C)(C)C3)CC2)C=C1)NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCN(C)CCOCCOCCOCCNC7=C8C(C(N(C9CCC(NC9=O)=O)C8=O)=O)=CC=C7)C=C5)(=O)=O

Molecular Formula

C65H76ClF3N8O12S3

Molecular Weight

1349.99

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Xuan Zhang, et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.