PROTAC EZH2 Degrader-3
PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 PROTAC degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis ((Blue: cereblon ligand Pomalidomide , Black: linker HY-W361751; Pink: EZH2 inhibitor Tazemetostat (HY-13803) ).
Product Specifications
CAS Number
3098718-46-5
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ezh2-degrader-3.html
Smiles
CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCN(C(CC5CCC(CNC6=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=CC=C6)CC5)=O)CC4)C=C3)=CC(C(NCC9=C(C)C=C(C)NC9=O)=O)=C2C
Molecular Formula
C56H68N8O8
Molecular Weight
981.19
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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