PROTAC EZH2 Degrader-3
Product Specifications
UNSPSC Description
PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 PROTAC degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis((Blue: cereblon ligand Pomalidomide (HY-10984), Black: linker HY-W361751；Pink: EZH2 inhibitor Tazemetostat (HY-13803))[1].
Target Antigen
Apoptosis; Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ezh2-degrader-3.html
Smiles
CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCN(C(CC5CCC(CNC6=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=CC=C6)CC5)=O)CC4)C=C3)=CC(C(NCC9=C(C)C=C(C)NC9=O)=O)=C2C
Molecular Weight
981.19
References & Citations
[1]Fu M, et al. Chemically induced degradation of PRC2 complex by EZH2-Targeted PROTACs via a Ubiquitin-Proteasome pathway. Bioorg Med Chem Lett. 2024;113:129968.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168131/PROTAC-EZH2-Degrader-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168131/
Clinical Information
No Development Reported
Curated Selection
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