Phospholipase C beta 3/PLCB3 Recombinant Rabbit Monoclonal Antibody [JE39-14]
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene. The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Phosphoinositide phospholipase C-beta-3 Phospholipase C-beta-3 (PLC-beta-3) PLCB3
Swiss Prot
Q01970 Human
Cellular Locus
Cytoplasm. Membrane. Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human Phospholipase C beta 3/PLCB3 aa 1,161-1,210 / 1,234.
Isotype
IgG
Clone
JE39-14
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
K-562 cell lysate, MCF7 cell lysate, HeLa cell lysate, HCT 116 cell lysate, SH-SY5Y cell lysate, human small intestine tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:2,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 139 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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