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Rutin (trihydrate)

Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities [1][2][3].

Product Specifications

CAS Number

250249-75-3

Product Name Alternative

Rutoside (trihydrate) ; Quercetin 3-O-rutinoside (trihydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/rutin-trihydrate.html

Purity

97.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15.O.O.O

Molecular Formula

C27H36O19

Molecular Weight

664.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Mel MMRD, et al. Formulation of microencapsulated rutin and evaluation of bioactivity and stability upon in vitro digestive and dialysis conditions. Int J Biol Macromol. 2020;159:316-323.|[2]Doostkam A, et al. Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model. Clin Exp Otorhinolaryngol. 2021;14 (3) :259-267.|[3]Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23 (9) :860-873.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

ACS Omega. 2024 Feb 28;9 (10) :11870-11882.|Adv Sci (Weinh) . 2022 Dec;9 (34) :e2203088.|Antioxidants (Basel) . 2023 Nov 7;12 (11) :1974.|Biology (Basel) . 2024 Aug 29;13 (9) :676.|Eur J Pharmacol. 2025 Jul 5:998:177536.|Eur Rev Med Pharmacol Sci. 2025 Sep;29 (9) :425-433.|Food Chem. 2022 May 1:375:131872.|Food Chem. 2023 Mar 30;405 (Pt A) :134807.|Food Chem. 2025 Dec 30:497:146992.|Food Chem. 2025 May 31:489:144992.|Food Funct. 2025 Oct 27;16 (21) :8548-8563.|Food Res Int. 2024 Oct:193:114812.|iScience. 2023 Sep 9;26 (10) :107866.|Neuron. 2025 Jul 23;113 (14) :2280-2296.e8.|Pharmacogn Mag. 2023 Oct 12.|Phytomedicine. 2023 Apr:112:154700.|Phytomedicine. 2025 Sep 15:148:157267.|Regulatory Research and Medicine Evaluation. 2025.|SSRN. 2025 Mar 20.|SSRN. 2025 Oct 6.|Arch Endocrinol Metab. 2025 Aug 20;69 (4) :e240410.|Cell Death Differ. 2025 Jun;32 (6) :1041-1057.|Neurotoxicology. 2024 Jul 18:S0161-813X (24) 00082-2.

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