2-Keto Crizotinib
2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.
Product Specifications
CAS Number
1415558-82-5
Product Name Alternative
PF-06260182
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-06260182.html
Solubility
10 mM in DMSO
Smiles
O=C1CC(N2N=CC(C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=C3)=C2)CCN1
Molecular Formula
C21H20Cl2FN5O2
Molecular Weight
464.32
References & Citations
[1]Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79 (1) :181-187.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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