What is the catalog number for NQDI-1?

The catalog number for NQDI-1 is HY-19566.

What sizes are available for NQDI-1?

NQDI-1 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does NQDI-1 come in?

NQDI-1 is available in 5 different pack sizes.

NQDI-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures NQDI-1?

NQDI-1 is manufactured by QuantiMol.

What is the estimated delivery time for NQDI-1?

Estimated delivery time for NQDI-1 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for NQDI-1?

The safety data sheet for NQDI-1 is available here: http://file.medchemexpress.com/batch_PDF/HY-19566/NQDI-1-SDS-MedChemExpress.pdf.

NQDI-1

NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM and an IC50 of 3 μM.

Product Specifications

CAS Number

175026-96-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; MAP3K

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NQDI-1.html

Concentration

10mM

Purity

98.11

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C2C3=C(NC1=O)C=CC=C3C(C4=C2C=CC=C4)=O)OCC

Molecular Formula

C19H13NO4

Molecular Weight

319.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Volynets GP, et al. Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1) . J Med Chem. 2011 Apr 28;54 (8) :2680-6.|[2]Hao H, et al. NQDI-1, an inhibitor of ASK1 attenuates acute perinatal hypoxic-ischemic cerebral injury by modulating cell death. Mol Med Rep. 2016 Jun;13 (6) :4585-92.