Anacardic Acid

Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively.

Product Specifications

CAS Number

[16611-84-0]

Product Name Alternative

Hydroginkgolic acid; Ginkgolic Acid C15:0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Epigenetic Reader Domain; Histone Acetyltransferase

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Anacardic_Acid.html

Purity

98.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1O

Molecular Formula

C22H36O3

Molecular Weight

348.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Balasubramanyam K, et al. Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 2003 May 23;278 (21) :19134-40. Epub 2003 Mar 6.|[2]Peng C, et al. Phenylephrine-induced cardiac hypertrophy is attenuated by a histone acetylase inhibitor anacardic acid in mice. Mol Biosyst. 2017 Mar 28;13 (4) :714-724.|[3]Muzaffar S, et al. Anacardic acid induces apoptosis-like cell death in the rice blast fungus Magnaporthe oryzae. Appl Microbiol Biotechnol. 2016 Jan;100 (1) :323-35.