Silperisone (hydrochloride)

Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis[1][2][3].

Product Specifications

CAS Number

[140944-30-5]

Product Name Alternative

RGH-5002

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/silperisone-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C[Si](C)(CN2CCCCC2)C)C=C1.Cl

Molecular Formula

C15H25ClFNSi

Molecular Weight

301.90

References & Citations

[1]Farkas S, et al. Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs[J]. Journal of Pharmacological and Toxicological methods, 2005, 52 (2) : 264-273.|[2]Kocsis P, et al. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315 (3) : 1237-1246.|[3]Farkas S, et al. Silperisone: a centrally acting muscle relaxant[J]. CNS Drug Reviews, 2006, 12 (3‐4) : 218-235.