L-Eflornithine (monohydrochloride)

L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1].

Product Specifications

CAS Number

[69955-42-6]

Product Name Alternative

L-DFMO (monohydrochloride) ; ; L-RMI71782 (monohydrochloride) ; L-α-difluoromethylornithine (monohydrochloride)

UNSPSC

12352211

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/L-Eflornithine_monohydrochloride.html

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@](CCCN)(C(F)F)C(O)=O.Cl

Molecular Formula

C6H13ClF2N2O2

Molecular Weight

218.63

References & Citations

[1]Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375 (Pt 2) :465-70.|[2]Jansson-Löfmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59 (2) :1299-307.