Tempone

Tempone (4-Oxo-Tempo) is a stable water-soluble nitro radical. Tempone is widely used as a contrast agent for metabolic activity and hypoxic sensitivity in electron spin resonance spectroscopy, magnetic resonance imaging and dynamic nuclear polarization. Tempone reduces superoxide radicals by mimicking the activity of superoxide dismutase (SOD), thereby reducing the formation of hydroxyl radicals and peroxynitrites. Tempone can be used in the study of ischemia-reperfusion injury and acute renal failure[1].

Product Specifications

CAS Number

[2896-70-0]

Product Name Alternative

4-Oxo-Tempo

UNSPSC

12352005

Hazard Statement

H302, H317, H372, H410

Target

SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tempone.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[O]N1C(C)(C)CC(CC1(C)C)=O

Molecular Formula

C9H16NO2?

Molecular Weight

170.23

Precautions

H302, H317, H372, H410

References & Citations

[1]Patel N S A, et al. TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney[J]. Free Radical Biology and Medicine, 2002, 33 (11) : 1575-1589.