Chst15-IN-1
Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1].
Product Specifications
CAS Number
[2158198-77-5]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
SULT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chst15-in-1.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(Cl)C=C1Cl)/C(C#N)=C/C2=CC(OC)=C(O)C(Br)=C2
Molecular Formula
C17H11BrCl2N2O3
Molecular Weight
442.09
Precautions
H302, H312, H332
References & Citations
[1]Cheung ST, et al. Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chem Biol. 2017;12 (12) :3126-3133.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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