IHR-1
IHR-1 is a cell membrane impermeable Smo antagonist[1].
Product Specifications
CAS Number
[548779-60-8]
UNSPSC
12352005
Hazard Statement
H302, H411
Target
Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ihr-1.html
Purity
98.05
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(C=CC(Cl)=C1)Cl)NC(C=C2)=CC=C2NC(C3=C(C=CC(Cl)=C3)Cl)=O
Molecular Formula
C20H12Cl4N2O2
Molecular Weight
454.13
Precautions
H302, H411
References & Citations
[1]Chih-Wei Fan, et al. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem Biol. 2014 Dec 18;21 (12) :1680-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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