ERα/ERβ antagonist-1

ERα/ERβ antagonist-1 (Compound 10) is partial antagonists of ERα and ERβ. ERα/ERβ antagonist-1 reduces ERα and ERβ activity in a dose-dependent manner in HepG2 liver cells[1].

Product Specifications

CAS Number

[2482778-93-6]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/erα-erβ-antagonist-1.html

Smiles

OC1=C(CC=C)C=C(C2=C(OC(CCC)=O)C=CC(CC=C)=C2)C=C1

Molecular Formula

C22H24O3

Molecular Weight

336.42

References & Citations

[1]Tinivella A, et al. Exploring Biological Targets of Magnolol and Honokiol and their Nature-Inspired Synthetic Derivatives: In Silico Identification and Experimental Validation of Estrogen Receptors. J Nat Prod. 2024 Nov 22;87 (11) :2568-2579.