Fludarabine (phosphate)

Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

Product Specifications

CAS Number

[75607-67-9]

Product Name Alternative

NSC 118218 (phosphate)

UNSPSC

12352005

Hazard Statement

H341, H361

Target

Apoptosis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Fludarabine-phosphate.html

Purity

99.77

Solubility

DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic)

Smiles

NC1=C2C(N([C@H]3[C@@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)C=N2)=NC(F)=N1

Molecular Formula

C10H13FN5O7P

Molecular Weight

365.21

Precautions

H341, H361

References & Citations

[1]Sorscher EJ, et al. In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase. Cancer Chemother Pharmacol. 2012 Aug;70 (2) :321-9.|[2]Kikuchi E, et al. Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts. Cancer Gene Th