OTS193320
OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX[1].
Product Specifications
CAS Number
2093401-33-1
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ots193320.html
Purity
99.08
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[N+](C1=CC=C(CN[C@@H]2CC[C@H](NC3=CC4=NC(C5=CC(Cl)=C(OC)C=C5OC)=CN4C=C3)CC2)C=C1)[O-]
Molecular Formula
C28H30ClN5O4
Molecular Weight
536.02
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SUV39H2/KMT1B
Available Sizes
Frequently Asked Questions
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