Pamoic acid
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].
Product Specifications
CAS Number
130-85-8
Product Name Alternative
Embonic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ERK; GPR35
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pamoic-acid.html
Purity
99.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C(O)=O)C=C2C(C=CC=C2)=C1CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4
Molecular Formula
C23H16O6
Molecular Weight
388.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10 (1) :9400. |[2]Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78 (4) :560-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Citation 01
Clin Transl Med. 2025 Apr;15 (4) :e70311.|Curr Eye Res. 2025 Jun 24:1-9.|Int Immunopharmacol. 2024 Jul 23:139:112720.|Eur J Med Chem. 2024 Dec 5:279:116842.|Noncoding RNA Res. 2025 May 15:13:184-196.
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