Pamoic acid

Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2].

Product Specifications

CAS Number

[130-85-8]

Product Name Alternative

Embonic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ERK; GPR35

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pamoic-acid.html

Purity

99.69

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(C(O)=O)C=C2C(C=CC=C2)=C1CC3=C(O)C(C(O)=O)=CC4=C3C=CC=C4

Molecular Formula

C23H16O6

Molecular Weight

388.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10 (1) :9400. |[2]Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78 (4) :560-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 4

Citation 01

Clin Transl Med. 2025 Apr;15 (4) :e70311.|Curr Eye Res. 2025 Jun 24:1-9.|Int Immunopharmacol. 2024 Jul 23:139:112720.|Eur J Med Chem. 2024 Dec 5:279:116842.|Noncoding RNA Res. 2025 May 15:13:184-196.