5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1].

Product Specifications

CAS Number

[131123-76-7]

Product Name Alternative

5,7-DCKA

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-7-dichlorokynurenic-acid.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1)O

Molecular Formula

C10H5Cl2NO3

Molecular Weight

258.06

Precautions

H315, H319, H335

References & Citations

[1]D McNamara, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120 (1) :17-20.