Fmoc-Gly-Gly-D-Phe-OtBu

Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234) [1].

Product Specifications

CAS Number

[2749985-44-0]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-gly-gly-d-phe-otbu.html

Purity

98.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](NC(CNC(CNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O)=O)CC4=CC=CC=C4)OC(C)(C)C

Molecular Formula

C32H35N3O6

Molecular Weight

557.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bak A, et al. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy) alkoxy linker. J Pept Res. 1999 Apr;53 (4) :393-402.