Telotristat ethyl

Telotristat ethyl (LX1032) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Product Specifications

CAS Number

[1033805-22-9]

Product Name Alternative

LX1032; LX1606

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lx1606.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : ≥ 101.5 mg/mL

Smiles

N[C@@H](CC1=CC=C(C2=NC(N)=NC(O[C@H](C3=CC=C(Cl)C=C3N4N=C(C)C=C4)C(F)(F)F)=C2)C=C1)C(OCC)=O

Molecular Formula

C27H26ClF3N6O3

Molecular Weight

574.98

Precautions

H315, H319, H320

References & Citations

[1]Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.|[2]Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Ecotoxicol Environ Saf. 2025 Jan 22:290:117764.|Microb Biotechnol. 2025 Nov;18 (11) :e70257.|Nutrients. 2021 Dec 28;14 (1) :117.|mBio. 2025 Aug 13;16 (8) :e0097625.