Tubulin polymerization/V-ATPase-IN-1
Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Proton Pump
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-v-atpase-in-1.html
Solubility
10 mM in DMSO
Smiles
COC(C(Cl)=CC(C1=NC(C(N)=O)=CC2=C1C=C3C(OCCO3)=C2)=C4)=C4OC
Molecular Formula
C20H17ClN2O5
Molecular Weight
400.81
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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