Tubulin polymerization/V-ATPase-IN-1

Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Proton Pump

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-v-atpase-in-1.html

Solubility

10 mM in DMSO

Smiles

COC(C(Cl)=CC(C1=NC(C(N)=O)=CC2=C1C=C3C(OCCO3)=C2)=C4)=C4OC

Molecular Formula

C20H17ClN2O5

Molecular Weight

400.81

References & Citations

[1]Leng J, et al. Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction. J Med Chem. 2024 Feb 22;67 (4) :3144-3166.