Tubulin polymerization/V-ATPase-IN-1
Product Specifications
UNSPSC Description
Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration[1].
Target Antigen
Apoptosis; Microtubule/Tubulin; Proton Pump
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-v-atpase-in-1.html
Solubility
10 mM in DMSO
Smiles
COC(C(Cl)=CC(C1=NC(C(N)=O)=CC2=C1C=C3C(OCCO3)=C2)=C4)=C4OC
Molecular Weight
400.81
References & Citations
[1]Leng J, et al. Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction. J Med Chem. 2024 Feb 22;67(4):3144-3166.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162264/Tubulin-polymerization-V-ATPase-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162264/
Clinical Information
No Development Reported
Curated Selection
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