1-Aminobenzotriazole
1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 (P450) .
Product Specifications
CAS Number
1614-12-6
Product Name Alternative
ABT; 3-Aminobenzotriazole
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-Aminobenzotriazole.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
NN1N=NC2=CC=CC=C21
Molecular Formula
C6H6N4
Molecular Weight
134.14
Precautions
H315, H319, H335
References & Citations
[1]Yang K, et al. Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes. Drug Metab Lett. 2010 Aug;4 (3) :129-33.|[2]Sun Q, et al. 1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase. Drug Metab Dispos. 2011 Sep;39 (9) :1674-9.|[3]Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42 (7) :1117-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2; CYP3
Available Sizes
Frequently Asked Questions
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