1-Aminobenzotriazole

1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 (P450) .

Product Specifications

CAS Number

[1614-12-6]

Product Name Alternative

ABT; 3-Aminobenzotriazole

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-Aminobenzotriazole.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

NN1N=NC2=CC=CC=C21

Molecular Formula

C6H6N4

Molecular Weight

134.14

Precautions

H315, H319, H335

References & Citations

[1]Yang K, et al. Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes. Drug Metab Lett. 2010 Aug;4 (3) :129-33.|[2]Sun Q, et al. 1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase. Drug Metab Dispos. 2011 Sep;39 (9) :1674-9.|[3]Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42 (7) :1117-24.