D-Tyrosine-d4

D-Tyrosine-d4 is the deuterium labeled D-Tyrosine (HY-Y0444) [1]. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[2][3].

Product Specifications

CAS Number

[944386-47-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Isotope-Labeled Compounds; Tyrosinase

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 1mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.1mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC([C@H](N)CC1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O

Molecular Formula

C9H7D4NO3

Molecular Weight

185.21

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Cong Yu, et al. Inhibition of Biofilm Formation by D-tyrosine: Effect of Bacterial Type and D-tyrosine Concentration. Water Res. 2016 Apr 1;92:173-9.|[3]Jisu Park, et al. D-tyrosine Negatively Regulates Melanin Synthesis by Competitively Inhibiting Tyrosinase Activity. Pigment Cell Melanoma Res. 2018 May;31 (3) :374-383.