TMP-153
TMP-153 is an orally active inhibitor of ACAT with an IC50 value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis[1].
Product Specifications
CAS Number
128831-46-9
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tmp-153.html
Purity
99.34
Smiles
O=C(NC1=CC=C(F)C=C1F)NC2=C(C3=CC=CC=C3Cl)C4=CC(C)=C(C)C=C4N=C2
Molecular Formula
C24H18ClF2N3O
Molecular Weight
437.87
References & Citations
[1]Sugiyama Y, et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis. 1995;113 (1) :71-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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