HA155

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3].

Product Specifications

CAS Number

[1312201-00-5]

Product Name Alternative

KPT-8602,KPT-8602 (Z-isomer)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ha155.html

Purity

98.00

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O

Molecular Formula

C24H19BFNO5S

Molecular Weight

463.29

Precautions

H302, H315, H319

References & Citations

[1]Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112 (5) :2593-603.|[2]Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54 (13) :4619-26.|[3]Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286 (40) :34654-63.