HA155
HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3].
Product Specifications
CAS Number
1312201-00-5
Product Name Alternative
KPT-8602,KPT-8602 (Z-isomer)
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ha155.html
Purity
98.00
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O
Molecular Formula
C24H19BFNO5S
Molecular Weight
463.29
Precautions
H302, H315, H319
References & Citations
[1]Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112 (5) :2593-603.|[2]Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54 (13) :4619-26.|[3]Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286 (40) :34654-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Autotaxin
Available Sizes
Frequently Asked Questions
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