Cycloposine

Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound that may induce cyclopia in pregnant Mianyang embryos[1].

Product Specifications

CAS Number

[23185-94-6]

UNSPSC

12352005

Hazard Statement

H301, H360

Target

Others

Type

Natural Products

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cycloposine.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 46.67 mg/mL (ultrasonic)

Smiles

CC1=C(C[C@@]2([H])[C@@]3([H])CC=C4[C@@]2(CC[C@@H](C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)[C@@]3([H])CC[C@]16O[C@@]7([H])[C@](NC[C@H](C7)C)([H])[C@H]6C

Molecular Formula

C33H51NO7

Molecular Weight

573.76

Precautions

H301, H360

References & Citations

[1]Chandler CM, et, al. Improved extraction and complete mass spectral characterization of steroidal alkaloids from Veratrum californicum. Nat Prod Commun. 2013 Aug;8 (8) :1059-64.|[2]Keeler RF. Teratogenic compounds of Veratrum californicum (Durand) . VII. The structure of the glycosidic alkaloid cycloposine. Steroids. 1969 May;13 (5) :579-88.|[3]Heretsch P, et al. Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives. Angew Chem Int Ed Engl. 2010 May 3;49 (20) :3418-27.