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GGFG-amide-glycol-amide-Exatecan

GGFG-amide-glycol-amide-Exatecan (Intermediate 2) is an Exatecan (HY-13631) derivative and can be used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[2866301-18-8]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ggfg-amide-glycol-amide-exatecan.html

Purity

98.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(NCOCCOC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O)=O

Molecular Formula

C43H47FN8O11

Molecular Weight

870.88

References & Citations

[1]Marija VRLJIC, et al. Exatecan derivatives and antibody-drug conjugates thereof. WO2022236136A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Camptothecins

Available Sizes

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