C1A

C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells[1].

Product Specifications

CAS Number

[1021463-02-4]

UNSPSC

12352005

Target

Apoptosis; HDAC; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c1a.html

Smiles

ClCCN(C1=CC=C(C=C1)S(NC2=CC=C(C=C2)/C=C(C)/C=C/C(NO)=O)(=O)=O)CCCl

Molecular Formula

C22H25Cl2N3O4S

Molecular Weight

498.42

References & Citations

[1]M Kaliszczak, et al. A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br J Cancer. 2013 Feb 5;108 (2) :342-50.