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EIF4A3-IN-8

EIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex) [1].

Product Specifications

CAS Number

18474-59-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eif4a3-in-8.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=CC2=C1C=C(C)C=C2)O

Molecular Formula

C10H9NO2

Molecular Weight

175.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Ito M, et al. Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem. 2017 Apr 1;25 (7) :2200-2209.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EIF4

Available Sizes

Frequently Asked Questions

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